Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 4
DEVELOPMENT AND CHARACTERIZATION OF BIOADHESIVE VAGINAL FILMS OF CLOTRIMAZOLE FOR VAGINAL CANDIDIASIS
BHAT R SUDEENDRA, HANİ UMME, RİTESH KUMAR GUPTA, H G SHİVAKUMAR
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore, Karnataka, India The purpose of this work was to design and optimize bioadhesive vaginal films of clotrimazole that could be retained in the vagina for prolonged period for more effective treatment against vaginal candidiasis. Bioadhesive films were formulated by solvent casting technique using bioadhesive polymers such as chitosan, HPMC and sodium CMC. Glycerine and PEG-400 were used as plasticizer. The films were characterized for various physical, mechanical, and aesthetic properties. Bioadhesive strength, antifungal activity and in vitro release studies suggested that the prolonged release bioadhesive vaginal film formulation of clotrimazole is useful and effective dosage form for treating vaginal candidiasis. Keywords : VAGINAL CANDIDIASIS, CLOTRIMAZOLE, BIOADHESIVE VAGINAL FILM, CHITOSAN, HPMC, SODIUM CMC

Istanbul Medipol University